03 Bacteria Virulence
![](https://i.imgur.com/ZLfOmQH.jpg)
Protein A
![](https://i.imgur.com/O1M5wxg.jpg)
.
![](https://i.imgur.com/ZSSmDBX.jpg)
IgA Protease
![](https://i.imgur.com/DRC3pt7.jpg)
M Protein
![](https://i.imgur.com/JHFDJ9z.jpg)
![](https://i.imgur.com/ziJ9YXl.jpg)
![](https://i.imgur.com/vsX59bX.jpg)
.
Endotoxin
- LPS with lipid A mostly responsible for toxicity
- O antigen do not cause disease by themselves
![](https://i.imgur.com/xKNygmb.jpg)
![](https://i.imgur.com/ILdtEdG.jpg)
- c3a and c5a anaphylaxis reaction
- low bp: hypotension/shock
![](https://i.imgur.com/KRLyURz.jpg)
LOS
![](https://i.imgur.com/ATzLMbg.jpg)
Exotoxins
![](https://i.imgur.com/WkD7WDF.jpg)
Protein synthesis inhibitors
![](https://i.imgur.com/uUp9nla.jpg)
.
ADP Ribosylation
![](https://i.imgur.com/L60avO9.jpg)
C. Diphtheria
![](https://i.imgur.com/yuhmTd3.jpg)
- ADP-ribose added to EF-2 from NAD that makes EF-2 nonfunctional
Pseudomonas aeruginosa
![](https://i.imgur.com/zzTBiEW.jpg)
Shigella
![](https://i.imgur.com/7SY2czT.jpg)
EHEC
![](https://i.imgur.com/USSZQx8.jpg)
![](https://i.imgur.com/oE2LRIK.jpg)
Fluid Secretion Toxins
![](https://i.imgur.com/qkzx4hW.jpg)
![](https://i.imgur.com/p166cLn.jpg)
ETEC
![](https://i.imgur.com/uAupfC5.jpg)
LT:
![](https://i.imgur.com/yF7FoBn.jpg)
ST:
![](https://i.imgur.com/a6fGW4q.jpg)
![](https://i.imgur.com/Y0ndKTz.jpg)
Bacillus Anthrax
![](https://i.imgur.com/1C0CRux.jpg)
Anthrax ulcers with necrotic center and edema borders:
![](https://i.imgur.com/fDViVy6.jpg)
![](https://i.imgur.com/wDvtfHu.jpg)
Phagocytosis Inhibitors
![](https://i.imgur.com/7S96qU9.jpg)
Neurotoxins
![](https://i.imgur.com/psySlZj.jpg)
![](https://i.imgur.com/3ZSQ2fl.jpg)
![](https://i.imgur.com/X17DF89.jpg)
Cell membrane lysis toxin
![](https://i.imgur.com/7ZaVwGk.jpg)
C. perfringens
![](https://i.imgur.com/5PFMxYA.jpg)
Strep pyogenes
- strep throat, rheumatic fever, glomerulonephritis
![](https://i.imgur.com/wHQzhsc.jpg)
![](https://i.imgur.com/OAezqux.jpg)
- C. diphtheria: virus delivers DNA to bacteria
Superantigens
- directly connects MHC to TCR and activates multiple T cells.
- Result: vasodilation and shock
![](https://i.imgur.com/4vBSzsd.jpg)
![](https://i.imgur.com/CrVTrz6.jpg)
TSST
- Sepsis does not have diarrhea and desquamation..
![](https://i.imgur.com/h2vK1rc.jpg)